Squalene Inhibits ATM-Dependent Signaling in γIR-Induced DNA Damage Response through Induction of Wip1 Phosphatase

Ataxia telangiectasia mutated (ATM) kinase plays a crucial role as a master controller in the cellular DNA damage response. Inhibition of ATM leads to inhibition of the checkpoint signaling pathway. Hence, addition of checkpoint inhibitors to anticancer therapies may be an effective targeting strate...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Tatewaki, Naoto, Konishi, Tetsuya, Nakajima, Yuki, Nishida, Miyako, Saito, Masafumi, Eitsuka, Takahiro, Sakamaki, Toshiyuki, Ikekawa, Nobuo, Nishida, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732816/
https://ncbi.nlm.nih.gov/pubmed/26824362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147570
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