Squalene Inhibits ATM-Dependent Signaling in γIR-Induced DNA Damage Response through Induction of Wip1 Phosphatase

Ataxia telangiectasia mutated (ATM) kinase plays a crucial role as a master controller in the cellular DNA damage response. Inhibition of ATM leads to inhibition of the checkpoint signaling pathway. Hence, addition of checkpoint inhibitors to anticancer therapies may be an effective targeting strate...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Tatewaki, Naoto, Konishi, Tetsuya, Nakajima, Yuki, Nishida, Miyako, Saito, Masafumi, Eitsuka, Takahiro, Sakamaki, Toshiyuki, Ikekawa, Nobuo, Nishida, Hiroshi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2016
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732816/
https://ncbi.nlm.nih.gov/pubmed/26824362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147570
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