Squalene Inhibits ATM-Dependent Signaling in γIR-Induced DNA Damage Response through Induction of Wip1 Phosphatase

Ataxia telangiectasia mutated (ATM) kinase plays a crucial role as a master controller in the cellular DNA damage response. Inhibition of ATM leads to inhibition of the checkpoint signaling pathway. Hence, addition of checkpoint inhibitors to anticancer therapies may be an effective targeting strate...

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Publicat a:PLoS One
Autors principals: Tatewaki, Naoto, Konishi, Tetsuya, Nakajima, Yuki, Nishida, Miyako, Saito, Masafumi, Eitsuka, Takahiro, Sakamaki, Toshiyuki, Ikekawa, Nobuo, Nishida, Hiroshi
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732816/
https://ncbi.nlm.nih.gov/pubmed/26824362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147570
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