Squalene Inhibits ATM-Dependent Signaling in γIR-Induced DNA Damage Response through Induction of Wip1 Phosphatase

Ataxia telangiectasia mutated (ATM) kinase plays a crucial role as a master controller in the cellular DNA damage response. Inhibition of ATM leads to inhibition of the checkpoint signaling pathway. Hence, addition of checkpoint inhibitors to anticancer therapies may be an effective targeting strate...

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發表在:PLoS One
Main Authors: Tatewaki, Naoto, Konishi, Tetsuya, Nakajima, Yuki, Nishida, Miyako, Saito, Masafumi, Eitsuka, Takahiro, Sakamaki, Toshiyuki, Ikekawa, Nobuo, Nishida, Hiroshi
格式: Artigo
語言:Inglês
出版: Public Library of Science 2016
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732816/
https://ncbi.nlm.nih.gov/pubmed/26824362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147570
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