ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage

The kinase ATR is activated by RPA-coated single-stranded DNA generated at aberrant replicative structures and resected double strand breaks. While many hundred candidate ATR substrates have been identified, the essential role of ATR in the replicative stress response has impeded the study of ATR ki...

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Hlavní autoři: Gamper, Armin M., Rofougaran, Reza, Watkins, Simon C., Greenberger, Joel S., Beumer, Jan H., Bakkenist, Christopher J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905881/
https://ncbi.nlm.nih.gov/pubmed/24038466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt833
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