PIDD mediates the association of DNA-PKcs and ATR at stalled replication forks to facilitate the ATR signaling pathway

The DNA-dependent protein kinase (DNA-PK), consisting of the DNA binding Ku70/80 heterodimer and the catalytic subunit DNA-PKcs, has been well characterized in the non-homologous end-joining mechanism for DNA double strand break (DSB) repair and radiation resistance. Besides playing a role in DSB re...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Lin, Yu-Fen, Shih, Hung-Ying, Shang, Zeng-Fu, Kuo, Ching-Te, Guo, Jiaming, Du, Chunying, Lee, Hsinyu, Chen, Benjamin P C
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
Genome Integrity, Repair and Replication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5829747/
https://ncbi.nlm.nih.gov/pubmed/29309644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1298
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