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DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response
The ataxia telangiectasia mutated and Rad3-related (ATR)-checkpoint kinase 1 (Chk1) axis is the major signaling pathway activated in response to replication stress and is essential for the intra-S checkpoint. ATR phosphorylates and activates a number of molecules to coordinate cell cycle progression...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3985680/ https://ncbi.nlm.nih.gov/pubmed/24500207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku116 |
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