DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response

The ataxia telangiectasia mutated and Rad3-related (ATR)-checkpoint kinase 1 (Chk1) axis is the major signaling pathway activated in response to replication stress and is essential for the intra-S checkpoint. ATR phosphorylates and activates a number of molecules to coordinate cell cycle progression...

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Autori principali: Lin, Yu-Fen, Shih, Hung-Ying, Shang, Zengfu, Matsunaga, Shinji, Chen, Benjamin PC
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
Soggetti:
Genome Integrity, Repair and Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985680/
https://ncbi.nlm.nih.gov/pubmed/24500207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku116
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