HERC2/USP20 coordinates CHK1 activation by modulating CLASPIN stability

CLASPIN is an essential mediator in the DNA replication checkpoint, responsible for ATR (ataxia telangiectasia and Rad3-related protein)-dependent activation of CHK1 (checkpoint kinase 1). Here we found a dynamic signaling pathway that regulates CLASPIN turn over. Under unperturbed conditions, the E...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Zhu, Min, Zhao, Hongchang, Liao, Ji, Xu, Xingzhi
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245974/
https://ncbi.nlm.nih.gov/pubmed/25326330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku978
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