Ataxin-3 promotes genome integrity by stabilizing Chk1

The Chk1 protein is essential for genome integrity maintenance and cell survival in eukaryotic cells. After prolonged replication stress, Chk1 can be targeted for proteasomal degradation to terminate checkpoint signaling after DNA repair finishes. To ensure proper activation of DNA damage checkpoint...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Tu, Yingfeng, Liu, Hongmei, Zhu, Xuefei, Shen, Hongyan, Ma, Xiaolu, Wang, Fengli, Huang, Min, Gong, Juanjuan, Li, Xiaoling, Wang, Yun, Guo, Caixia, Tang, Tie-Shan
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
Teme:
Genome Integrity, Repair and Replication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5416811/
https://ncbi.nlm.nih.gov/pubmed/28180282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx095
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