Ataxin-3 promotes genome integrity by stabilizing Chk1

The Chk1 protein is essential for genome integrity maintenance and cell survival in eukaryotic cells. After prolonged replication stress, Chk1 can be targeted for proteasomal degradation to terminate checkpoint signaling after DNA repair finishes. To ensure proper activation of DNA damage checkpoint...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Tu, Yingfeng, Liu, Hongmei, Zhu, Xuefei, Shen, Hongyan, Ma, Xiaolu, Wang, Fengli, Huang, Min, Gong, Juanjuan, Li, Xiaoling, Wang, Yun, Guo, Caixia, Tang, Tie-Shan
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
Matèries:
Genome Integrity, Repair and Replication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5416811/
https://ncbi.nlm.nih.gov/pubmed/28180282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx095
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