The dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is dependent on the complexity of damage

DNA double-strand breaks (DSBs) are biologically one of the most important cellular lesions and possess varying degrees of chemical complexity. The notion that the repairability of more chemically complex DSBs is inefficient led to the concept that the extent of DSB complexity underlies the severity...

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Bibliographische Detailangaben
Hauptverfasser: Reynolds, Pamela, Anderson, Jennifer A., Harper, Jane V., Hill, Mark A., Botchway, Stanley W., Parker, Anthony W., O’Neill, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2012
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510491/
https://ncbi.nlm.nih.gov/pubmed/23012265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks879
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