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Structural model of full-length human Ku70–Ku80 heterodimer and its recognition of DNA and DNA-PKcs
Recognition of DNA double-strand breaks during non-homologous end joining is carried out by the Ku70–Ku80 protein, a 150 kDa heterodimer that recruits the DNA repair kinase DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to the lesion. The atomic structure of a truncated Ku70–Ku80 was dete...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1796749/ https://ncbi.nlm.nih.gov/pubmed/17159921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400847 |
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