The dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is dependent on the complexity of damage

DNA double-strand breaks (DSBs) are biologically one of the most important cellular lesions and possess varying degrees of chemical complexity. The notion that the repairability of more chemically complex DSBs is inefficient led to the concept that the extent of DSB complexity underlies the severity...

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Autores principales: Reynolds, Pamela, Anderson, Jennifer A., Harper, Jane V., Hill, Mark A., Botchway, Stanley W., Parker, Anthony W., O’Neill, Peter
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2012
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510491/
https://ncbi.nlm.nih.gov/pubmed/23012265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks879
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