Real-time Visualization of Cytoplasmic Calpain Activation and Calcium Deregulation in Acute Glutamate Excitotoxicity

Although calpain (EC 3.4.22) protease activation was suggested to contribute to excitotoxic delayed calcium deregulation (DCD) via proteolysis of Na(+)/Ca(2+) exchanger 3 (NCX3), cytoplasmic calpain activation in relation to DCD has never been visualized in real time. We employed a calpain fluoresce...

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Bibliografische gegevens
Hoofdauteurs: Gerencser, Akos A., Mark, Karla A., Hubbard, Alan E., Divakaruni, Ajit S, Mehrabian, Zara, Nicholls, David G., Polster, Brian M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745075/
https://ncbi.nlm.nih.gov/pubmed/19493161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2009.06194.x
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