Real-time Visualization of Cytoplasmic Calpain Activation and Calcium Deregulation in Acute Glutamate Excitotoxicity

Although calpain (EC 3.4.22) protease activation was suggested to contribute to excitotoxic delayed calcium deregulation (DCD) via proteolysis of Na(+)/Ca(2+) exchanger 3 (NCX3), cytoplasmic calpain activation in relation to DCD has never been visualized in real time. We employed a calpain fluoresce...

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Detalhes bibliográficos
Main Authors: Gerencser, Akos A., Mark, Karla A., Hubbard, Alan E., Divakaruni, Ajit S, Mehrabian, Zara, Nicholls, David G., Polster, Brian M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745075/
https://ncbi.nlm.nih.gov/pubmed/19493161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2009.06194.x
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