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Calpain Activation and Na/Ca Exchanger Degradation Occur Downstream of Calcium Deregulation in Hippocampal Neurons Exposed to Excitotoxic Glutamate

Delayed calcium deregulation (DCD) plays an essential role in glutamate excitotoxicity, a major detrimental factor in stroke, traumatic brain injury, and various neurodegenerations. In the present study, we examined the role of calpain activation and Na(+)/Ca(2+) exchanger (NCX) degradation in DCD a...

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Bibliographic Details
Main Authors: Brustovetsky, Tatiana, Bolshakov, Alexey, Brustovetsky, Nickolay
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830319/
https://ncbi.nlm.nih.gov/pubmed/19937813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.22295
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