Real-time Visualization of Cytoplasmic Calpain Activation and Calcium Deregulation in Acute Glutamate Excitotoxicity

Although calpain (EC 3.4.22) protease activation was suggested to contribute to excitotoxic delayed calcium deregulation (DCD) via proteolysis of Na(+)/Ca(2+) exchanger 3 (NCX3), cytoplasmic calpain activation in relation to DCD has never been visualized in real time. We employed a calpain fluoresce...

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Главные авторы: Gerencser, Akos A., Mark, Karla A., Hubbard, Alan E., Divakaruni, Ajit S, Mehrabian, Zara, Nicholls, David G., Polster, Brian M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745075/
https://ncbi.nlm.nih.gov/pubmed/19493161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2009.06194.x
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