Divergent regulation of GIRK1 and GIRK2 subunits of the neuronal G protein gated K(+) channel by Gα(i)(GDP) and Gβγ

G protein activated K(+) channels (GIRK, Kir3) are switched on by direct binding of Gβγ following activation of G(i/o) proteins via G protein-coupled receptors (GPCRs). Although Gα(i) subunits do not activate GIRKs, they interact with the channels and regulate the gating pattern of the neuronal hete...

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Hlavní autoři: Rubinstein, Moran, Peleg, Sagit, Berlin, Shai, Brass, Dovrat, Keren-Raifman, Tal, Dessauer, Carmen W, Ivanina, Tatiana, Dascal, Nathan
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2009
Témata:
Molecular and Cellular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742276/
https://ncbi.nlm.nih.gov/pubmed/19470775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2009.173229
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