Gα(i3) primes the G protein-activated K(+) channels for activation by coexpressed Gβγ in intact Xenopus oocytes

G protein-activated K(+) channels (GIRK) mediate postsynaptic inhibitory effects of neurotransmitters in the atrium and in the brain by coupling to G protein-coupled receptors (GPCRs). In neurotransmitter-dependent GIRK signalling, Gβγ is released from the heterotrimeric Gαβγ complex upon GPCR activ...

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Bibliographische Detailangaben
Hauptverfasser: Rubinstein, Moran, Peleg, Sagit, Berlin, Shai, Brass, Dovrat, Dascal, Nathan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2007
Schlagworte:
Molecular And Genomic
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2075207/
https://ncbi.nlm.nih.gov/pubmed/17289785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.125864
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