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Gα(i3) primes the G protein-activated K(+) channels for activation by coexpressed Gβγ in intact Xenopus oocytes
G protein-activated K(+) channels (GIRK) mediate postsynaptic inhibitory effects of neurotransmitters in the atrium and in the brain by coupling to G protein-coupled receptors (GPCRs). In neurotransmitter-dependent GIRK signalling, Gβγ is released from the heterotrimeric Gαβγ complex upon GPCR activ...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Blackwell Science Inc
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2075207/ https://ncbi.nlm.nih.gov/pubmed/17289785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.125864 |
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