Recruitment of Gβγ controls the basal activity of G-protein coupled inwardly rectifying potassium (GIRK) channels: crucial role of distal C terminus of GIRK1

The G-protein coupled inwardly rectifying potassium (GIRK, or Kir3) channels are important mediators of inhibitory neurotransmission via activation of G-protein coupled receptors (GPCRs). GIRK channels are tetramers comprising combinations of subunits (GIRK1–4), activated by direct binding of the Gβ...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Kahanovitch, Uri, Tsemakhovich, Vladimir, Berlin, Shai, Rubinstein, Moran, Styr, Boaz, Castel, Ruth, Peleg, Sagit, Tabak, Galit, Dessauer, Carmen W, Ivanina, Tatiana, Dascal, Nathan
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2014
Assuntos:
Molecular and Cellular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270501/
https://ncbi.nlm.nih.gov/pubmed/25384780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2014.283218
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