Gα(i) and Gβγ Jointly Regulate the Conformations of a Gβγ Effector, the Neuronal G Protein-activated K(+) Channel (GIRK)

Stable complexes among G proteins and effectors are an emerging concept in cell signaling. The prototypical Gβγ effector G protein-activated K(+) channel (GIRK; Kir3) physically interacts with Gβγ but also with Gα(i/o). Whether and how Gα(i/o) subunits regulate GIRK in vivo is unclear. We studied tr...

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Autores principales: Berlin, Shai, Keren-Raifman, Tal, Castel, Ruth, Rubinstein, Moran, Dessauer, Carmen W., Ivanina, Tatiana, Dascal, Nathan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825413/
https://ncbi.nlm.nih.gov/pubmed/20018875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.085944
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