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Gα(i) and Gβγ Jointly Regulate the Conformations of a Gβγ Effector, the Neuronal G Protein-activated K(+) Channel (GIRK)
Stable complexes among G proteins and effectors are an emerging concept in cell signaling. The prototypical Gβγ effector G protein-activated K(+) channel (GIRK; Kir3) physically interacts with Gβγ but also with Gα(i/o). Whether and how Gα(i/o) subunits regulate GIRK in vivo is unclear. We studied tr...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2825413/ https://ncbi.nlm.nih.gov/pubmed/20018875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.085944 |
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