Two Distinct Aspects of Coupling between Gα(i) Protein and G Protein-activated K(+) Channel (GIRK) Revealed by Fluorescently Labeled Gα(i3) Protein Subunits

G protein-activated K(+) channels (Kir3 or GIRK) are activated by direct interaction with Gβγ. Gα is essential for specific signaling and regulates basal activity of GIRK (I(basal)) and kinetics of the response elicited by activation by G protein-coupled receptors (I(evoked)). These regulations are...

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Detalhes bibliográficos
Main Authors: Berlin, Shai, Tsemakhovich, Vladimir A., Castel, Ruth, Ivanina, Tatiana, Dessauer, Carmen W., Keren-Raifman, Tal, Dascal, Nathan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190912/
https://ncbi.nlm.nih.gov/pubmed/21795707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.271056
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