Two Distinct Aspects of Coupling between Gα(i) Protein and G Protein-activated K(+) Channel (GIRK) Revealed by Fluorescently Labeled Gα(i3) Protein Subunits

G protein-activated K(+) channels (Kir3 or GIRK) are activated by direct interaction with Gβγ. Gα is essential for specific signaling and regulates basal activity of GIRK (I(basal)) and kinetics of the response elicited by activation by G protein-coupled receptors (I(evoked)). These regulations are...

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Bibliografiske detaljer
Main Authors: Berlin, Shai, Tsemakhovich, Vladimir A., Castel, Ruth, Ivanina, Tatiana, Dessauer, Carmen W., Keren-Raifman, Tal, Dascal, Nathan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190912/
https://ncbi.nlm.nih.gov/pubmed/21795707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.271056
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