A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ

G protein-gated K(+) channels (GIRK; Kir3), activated by Gβγ subunits derived from G(i/o) proteins, regulate heartbeat and neuronal excitability and plasticity. Both neurotransmitter-evoked (I(evoked)) and neurotransmitter-independent basal (I(basal)) GIRK activities are physiologically important, b...

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Pubblicato in:PLoS Comput Biol
Autori principali: Yakubovich, Daniel, Berlin, Shai, Kahanovitch, Uri, Rubinstein, Moran, Farhy-Tselnicker, Isabella, Styr, Boaz, Keren-Raifman, Tal, Dessauer, Carmen W., Dascal, Nathan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636287/
https://ncbi.nlm.nih.gov/pubmed/26544551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004598
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