A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ

G protein-gated K(+) channels (GIRK; Kir3), activated by Gβγ subunits derived from G(i/o) proteins, regulate heartbeat and neuronal excitability and plasticity. Both neurotransmitter-evoked (I(evoked)) and neurotransmitter-independent basal (I(basal)) GIRK activities are physiologically important, b...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:PLoS Comput Biol
Main Authors: Yakubovich, Daniel, Berlin, Shai, Kahanovitch, Uri, Rubinstein, Moran, Farhy-Tselnicker, Isabella, Styr, Boaz, Keren-Raifman, Tal, Dessauer, Carmen W., Dascal, Nathan
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2015
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636287/
https://ncbi.nlm.nih.gov/pubmed/26544551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004598
תגים: הוספת תג
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

פריטים דומים