Metnase mediates chromosome decatenation in acute leukemia cells

After DNA replication, sister chromatids must be untangled, or decatenated, before mitosis so that chromatids do not tear during anaphase. Topoisomerase IIα (Topo IIα) is the major decatenating enzyme. Topo IIα inhibitors prevent decatenation, causing cells to arrest during mitosis. Here we report t...

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Autores principales: Wray, Justin, Williamson, Elizabeth A., Sheema, Sheema, Lee, Suk-Hee, Libby, Edward, Willman, Cheryl L., Nickoloff, Jac A., Hromas, Robert
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2009
Materias:
Myeloid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738570/
https://ncbi.nlm.nih.gov/pubmed/19458360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-08-175760
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