Metnase mediates chromosome decatenation in acute leukemia cells

After DNA replication, sister chromatids must be untangled, or decatenated, before mitosis so that chromatids do not tear during anaphase. Topoisomerase IIα (Topo IIα) is the major decatenating enzyme. Topo IIα inhibitors prevent decatenation, causing cells to arrest during mitosis. Here we report t...

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Bibliografische gegevens
Hoofdauteurs: Wray, Justin, Williamson, Elizabeth A., Sheema, Sheema, Lee, Suk-Hee, Libby, Edward, Willman, Cheryl L., Nickoloff, Jac A., Hromas, Robert
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2009
Onderwerpen:
Myeloid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738570/
https://ncbi.nlm.nih.gov/pubmed/19458360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-08-175760
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