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Metnase mediates chromosome decatenation in acute leukemia cells
After DNA replication, sister chromatids must be untangled, or decatenated, before mitosis so that chromatids do not tear during anaphase. Topoisomerase IIα (Topo IIα) is the major decatenating enzyme. Topo IIα inhibitors prevent decatenation, causing cells to arrest during mitosis. Here we report t...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society of Hematology
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2738570/ https://ncbi.nlm.nih.gov/pubmed/19458360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-08-175760 |
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