The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation

Metnase is a human SET and transposase domain protein that methylates histone H3 and promotes DNA double-strand break repair. We now show that Metnase physically interacts and co-localizes with Topoisomerase IIα (Topo IIα), the key chromosome decatenating enzyme. Metnase promotes progression through...

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Main Authors: Williamson, Elizabeth A., Rasila, Kanwaldeep Kaur, Corwin, Lori Kwan, Wray, Justin, Beck, Brian D., Severns, Virginia, Mobarak, Charlotte, Lee, Suk-Hee, Nickoloff, Jac A., Hromas, Robert
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2008
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566874/
https://ncbi.nlm.nih.gov/pubmed/18790802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn560
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