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The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair

The molecular mechanism by which foreign DNA integrates into the human genome is poorly understood yet critical to many disease processes, including retroviral infection and carcinogenesis, and to gene therapy. We hypothesized that the mechanism of genomic integration may be similar to transposition...

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Détails bibliographiques
Auteurs principaux: Lee, Suk-Hee, Oshige, Masahiko, Durant, Stephen T., Rasila, Kanwaldeep Kaur, Williamson, Elizabeth A., Ramsey, Heather, Kwan, Lori, Nickoloff, Jac A., Hromas, Robert
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2005
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1312370/
https://ncbi.nlm.nih.gov/pubmed/16332963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503676102
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