The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair

The molecular mechanism by which foreign DNA integrates into the human genome is poorly understood yet critical to many disease processes, including retroviral infection and carcinogenesis, and to gene therapy. We hypothesized that the mechanism of genomic integration may be similar to transposition...

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Detaylı Bibliyografya
Asıl Yazarlar: Lee, Suk-Hee, Oshige, Masahiko, Durant, Stephen T., Rasila, Kanwaldeep Kaur, Williamson, Elizabeth A., Ramsey, Heather, Kwan, Lori, Nickoloff, Jac A., Hromas, Robert
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2005
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1312370/
https://ncbi.nlm.nih.gov/pubmed/16332963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503676102
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