Metnase mediates chromosome decatenation in acute leukemia cells

After DNA replication, sister chromatids must be untangled, or decatenated, before mitosis so that chromatids do not tear during anaphase. Topoisomerase IIα (Topo IIα) is the major decatenating enzyme. Topo IIα inhibitors prevent decatenation, causing cells to arrest during mitosis. Here we report t...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Wray, Justin, Williamson, Elizabeth A., Sheema, Sheema, Lee, Suk-Hee, Libby, Edward, Willman, Cheryl L., Nickoloff, Jac A., Hromas, Robert
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2009
Gaiak:
Myeloid Neoplasia
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738570/
https://ncbi.nlm.nih.gov/pubmed/19458360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-08-175760
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