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Metnase Mediates Resistance to Topoisomerase II Inhibitors in Breast Cancer Cells
DNA replication produces tangled, or catenated, chromatids, that must be decatenated prior to mitosis or catastrophic genomic damage will occur. Topoisomerase IIα (Topo IIα) is the primary decatenating enzyme. Cells monitor catenation status and activate decatenation checkpoints when decatenation is...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2669129/ https://ncbi.nlm.nih.gov/pubmed/19390626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005323 |
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