Metnase Mediates Resistance to Topoisomerase II Inhibitors in Breast Cancer Cells

DNA replication produces tangled, or catenated, chromatids, that must be decatenated prior to mitosis or catastrophic genomic damage will occur. Topoisomerase IIα (Topo IIα) is the primary decatenating enzyme. Cells monitor catenation status and activate decatenation checkpoints when decatenation is...

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Bibliographic Details
Main Authors: Wray, Justin, Williamson, Elizabeth A., Royce, Melanie, Shaheen, Montaser, Beck, Brian D., Lee, Suk-Hee, Nickoloff, Jac A., Hromas, Robert
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669129/
https://ncbi.nlm.nih.gov/pubmed/19390626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005323
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