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Metnase Mediates Resistance to Topoisomerase II Inhibitors in Breast Cancer Cells
DNA replication produces tangled, or catenated, chromatids, that must be decatenated prior to mitosis or catastrophic genomic damage will occur. Topoisomerase IIα (Topo IIα) is the primary decatenating enzyme. Cells monitor catenation status and activate decatenation checkpoints when decatenation is...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2669129/ https://ncbi.nlm.nih.gov/pubmed/19390626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005323 |
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