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Inhibition of autotaxin production or activity blocks lysophosphatidylcholine-induced migration of human breast cancer and melanoma cells

Increased expression of autotaxin is linked to several malignancies including glioblastoma, breast, renal, ovarian, lung and thyroid cancers. Autotaxin promotes metastasis as well as cell growth, survival, and migration of cancer cells. These actions could depend on the non-catalytic effects of auto...

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Autori principali: Gaetano, Cristoforo G., Samadi, Nasser, Tomsig, Jose L., Macdonald, Timothy L., Lynch, Kevin R., Brindley, David N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736327/
https://ncbi.nlm.nih.gov/pubmed/19204929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.20524
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