Vinyl Sulfone Analogs of Lysophosphatidylcholine Irreversibly Inhibit Autotaxin and Prevent Angiogenesis in Melanoma

Autotaxin (ATX) is an enzyme discovered in the conditioned medium of cultured melanoma cells and identified as a protein that strongly stimulates motility. This unique ectonucleotide pyrophosphatase and phosphodiesterase facilitates the removal of a choline headgroup from lysophosphatidylcholine (LP...

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Gepubliceerd in:Bioorg Med Chem
Hoofdauteurs: Murph, Mandi M., Jiang, Guowei W., Altman, Molly K., Jia, Wei, Nguyen, Duy T., Fambrough, Jada M., Hardman, William J., Nguyen, Ha T., Tran, Sterling K., Alshamrani, Ali A., Madan, Damian, Zhang, Jianxing, Prestwich, Glenn D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4554797/
https://ncbi.nlm.nih.gov/pubmed/26190462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.06.054
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