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Aromatic Phosphonates Inhibit the Lysophospholipase D Activity of Autotaxin
Autotaxin (ATX) is an attractive target for the anticancer therapeutics that inhibit angiogenesis, invasion and migration. ATX is an extracellular lysophospholipase D that hydrolyzes lysophosphatidylcholine to form the bioactive lipid lysophosphatidic acid. The aromatic phosphonate S32826 was the fi...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3140587/ https://ncbi.nlm.nih.gov/pubmed/21489790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.03.068 |
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