Vinyl Sulfone Analogs of Lysophosphatidylcholine Irreversibly Inhibit Autotaxin and Prevent Angiogenesis in Melanoma

Autotaxin (ATX) is an enzyme discovered in the conditioned medium of cultured melanoma cells and identified as a protein that strongly stimulates motility. This unique ectonucleotide pyrophosphatase and phosphodiesterase facilitates the removal of a choline headgroup from lysophosphatidylcholine (LP...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem
Main Authors: Murph, Mandi M., Jiang, Guowei W., Altman, Molly K., Jia, Wei, Nguyen, Duy T., Fambrough, Jada M., Hardman, William J., Nguyen, Ha T., Tran, Sterling K., Alshamrani, Ali A., Madan, Damian, Zhang, Jianxing, Prestwich, Glenn D.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4554797/
https://ncbi.nlm.nih.gov/pubmed/26190462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.06.054
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