Vinyl Sulfone Analogs of Lysophosphatidylcholine Irreversibly Inhibit Autotaxin and Prevent Angiogenesis in Melanoma

Autotaxin (ATX) is an enzyme discovered in the conditioned medium of cultured melanoma cells and identified as a protein that strongly stimulates motility. This unique ectonucleotide pyrophosphatase and phosphodiesterase facilitates the removal of a choline headgroup from lysophosphatidylcholine (LP...

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Publicado en:Bioorg Med Chem
Main Authors: Murph, Mandi M., Jiang, Guowei W., Altman, Molly K., Jia, Wei, Nguyen, Duy T., Fambrough, Jada M., Hardman, William J., Nguyen, Ha T., Tran, Sterling K., Alshamrani, Ali A., Madan, Damian, Zhang, Jianxing, Prestwich, Glenn D.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4554797/
https://ncbi.nlm.nih.gov/pubmed/26190462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.06.054
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