Vinyl Sulfone Analogs of Lysophosphatidylcholine Irreversibly Inhibit Autotaxin and Prevent Angiogenesis in Melanoma

Autotaxin (ATX) is an enzyme discovered in the conditioned medium of cultured melanoma cells and identified as a protein that strongly stimulates motility. This unique ectonucleotide pyrophosphatase and phosphodiesterase facilitates the removal of a choline headgroup from lysophosphatidylcholine (LP...

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Vydáno v:Bioorg Med Chem
Hlavní autoři: Murph, Mandi M., Jiang, Guowei W., Altman, Molly K., Jia, Wei, Nguyen, Duy T., Fambrough, Jada M., Hardman, William J., Nguyen, Ha T., Tran, Sterling K., Alshamrani, Ali A., Madan, Damian, Zhang, Jianxing, Prestwich, Glenn D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4554797/
https://ncbi.nlm.nih.gov/pubmed/26190462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.06.054
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