Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors

We present a strategy for adoptive immunotherapy using T-lineage committed lymphoid precursor cells generated by Notch1-based culture. We found that allogeneic T-cell precursors can be transferred to irradiated individuals irrespective of major histocompatibility complex (MHC) disparities and give r...

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Main Authors: Zakrzewski, Johannes L, Suh, David, Markley, John C, Smith, Odette M, King, Christopher, Goldberg, Gabrielle L, Jenq, Robert, Holland, Amanda M, Grubin, Jeremy, Cabrera-Perez, Javier, Brentjens, Renier J, Lu, Sydney X, Rizzuto, Gabrielle, Sant’Angelo, Derek B, Riviere, Isabelle, Sadelain, Michel, Heller, Glenn, Zúñiga-Pflücker, Juan Carlos, Lu, Chen, van den Brink, Marcel R M
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2731996/
https://ncbi.nlm.nih.gov/pubmed/18376399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt1395
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