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SH2 dependent autophosphorylation within the Tec family kinase Itk

The Tec family kinase, Itk, undergoes an in cis autophosphorylation on Y180 within its SH3 domain. Autophosphorylation of the Itk SH3 domain by the Itk kinase domain is strictly dependent on the presence of the intervening SH2 domain. A direct docking interaction between the Itk kinase and SH2 domai...

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Autors principals: Joseph, Raji E., Severin, Andrew, Min, Lie, Fulton, D. Bruce, Andreotti, Amy H.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722949/
https://ncbi.nlm.nih.gov/pubmed/19523959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.06.023
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