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Proline isomerization preorganizes the Itk SH2 domain for binding the Itk SH3 domain
We report here the NMR derived structure of the binary complex formed by the Itk SH3 and SH2 domains. The interaction is independent of both a phosphotyrosine motif and a proline-rich sequence; the classical targets of the SH2 and SH3 domain, respectively. The Itk SH3/SH2 structure reveals the molec...
Tallennettuna:
| Päätekijät: | , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2009
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2810249/ https://ncbi.nlm.nih.gov/pubmed/19361414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.02.012 |
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