Proline isomerization preorganizes the Itk SH2 domain for binding the Itk SH3 domain

We report here the NMR derived structure of the binary complex formed by the Itk SH3 and SH2 domains. The interaction is independent of both a phosphotyrosine motif and a proline-rich sequence; the classical targets of the SH2 and SH3 domain, respectively. The Itk SH3/SH2 structure reveals the molec...

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Detaylı Bibliyografya
Asıl Yazarlar: Severin, Andrew, Joseph, Raji E., Boyken, Scott, Fulton, D. Bruce, Andreotti, Amy H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810249/
https://ncbi.nlm.nih.gov/pubmed/19361414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.02.012
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