Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCγ1

Interleukin-2 tyrosine kinase (Itk) is a Tec family tyrosine kinase that mediates signaling processes after T cell receptor engagement. Activation of Itk requires recruitment to the membrane via its pleckstrin homology domain, phosphorylation of Itk by the Src kinase, Lck, and binding of Itk to the...

Full description

Saved in:
Bibliographic Details
Main Authors: Min, Lie, Joseph, Raji E., Fulton, D. Bruce, Andreotti, Amy H.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786894/
https://ncbi.nlm.nih.gov/pubmed/19955438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911309106
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items