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Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCγ1
Interleukin-2 tyrosine kinase (Itk) is a Tec family tyrosine kinase that mediates signaling processes after T cell receptor engagement. Activation of Itk requires recruitment to the membrane via its pleckstrin homology domain, phosphorylation of Itk by the Src kinase, Lck, and binding of Itk to the...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2786894/ https://ncbi.nlm.nih.gov/pubmed/19955438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911309106 |
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