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Substrate Recognition of PLCγ1 via a Specific Docking Surface on Itk

Itk (interleukin-2 inducible T cell kinase) is a non-receptor protein tyrosine kinase expressed primarily in T cells. Itk catalyzes phosphorylation on tyrosine residues within a number of its natural substrates, including the well-characterized Y783 of PLCγ1. However, the molecular mechanisms Itk ex...

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Detalhes bibliográficos
Main Authors: Xie, Qian, Joseph, Raji E., Fulton, D. Bruce, Andreotti, Amy H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880187/
https://ncbi.nlm.nih.gov/pubmed/23219468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.10.023
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