Cyclin D1 is frequently overexpressed in microsatellite unstable colorectal cancer, independent of CpG island methylator phenotype

AIMS: Cyclin D1 and cyclin-dependent kinases are commonly activated in colorectal cancer. Microsatellite instability (MSI) and CpG island methylator phenotype (CIMP) are important molecular classifiers in colorectal cancer. However, the relationship between cyclin D1, MSI and CIMP has been uncertain...

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Main Authors: Nosho, Katsuhiko, Kawasaki, Takako, Chan, Andrew T., Ohnishi, Mutsuko, Suemoto, Yuko, Kirkner, Gregory J., Fuchs, Charles S., Ogino, Shuji
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719983/
https://ncbi.nlm.nih.gov/pubmed/18983468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2559.2008.03161.x
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