CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer

BACKGROUND: The CpG island methylator phenotype (CIMP) characterized by widespread promoter methylation is associated with microsatellite instability (MSI) and BRAF mutation in colorectal cancer. The independent effect of CIMP, MSI and BRAF mutation on patient outcome remains uncertain. METHODS: Uti...

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Main Authors: Ogino, Shuji, Nosho, Katsuhiko, Kirkner, Gregory J., Kawasaki, Takako, Meyerhardt, Jeffrey A., Loda, Massimo, Giovannucci, Edward L., Fuchs, Charles S.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679586/
https://ncbi.nlm.nih.gov/pubmed/18832519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2008.155473
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