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The Sequence Dependence of Human Nucleotide Excision Repair Efficiencies of Benzo[a]pyrene-Derived DNA Lesions: Insights into the Structural Factors that Favor Dual Incisions
Nucleotide excision repair (NER) is a vital cellular defense system against carcinogen-DNA adducts, which, if not repaired, can initiate cancer development. The structural features of bulky DNA lesions that account for differences in NER efficiencies in mammalian cells are not well understood. In vi...
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| Autori principali: | , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2717896/ https://ncbi.nlm.nih.gov/pubmed/19162041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.12.082 |
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