Distant neighbor base sequence context effects in human nucleotide excision repair of a benzo[a]pyrene-derived DNA lesion

The effects of non-nearest base sequences, beyond the nucleotides flanking a DNA lesion on either side, on nucleotide excision repair (NER) in extracts from human cells were investigated. We constructed two duplexes containing the same minor groove-aligned 10S (+)-trans-anti-B[a]P-N(2)-dG (G*) DNA a...

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Autores principales: Cai, Yuqin, Kropachev, Konstantin, Xu, Rong, Tang, Yijin, Kolbanovskii, Marina, Kolbanovskii, Alexander, Amin, Shantu, Patel, Dinshaw J., Broyde, Suse, Geacintov, Nicholas E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923096/
https://ncbi.nlm.nih.gov/pubmed/20399214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.04.004
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