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Autotaxin Structure Activity Relationships Revealed through Lysophosphatidylcholine Analogs

Autotaxin (ATX) catalyzes the hydrolysis of lysophosphatidylcholine (LPC) to form the bioactive lipid lysophosphatidic acid (LPA). LPA stimulates cell proliferation, cell survival, and cell migration and is involved in obesity, rheumatoid arthritis, neuropathic pain, atherosclerosis and various canc...

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Autori principali: North, E. Jeffrey, Osborne, Daniel A., Bridson, Peter K., Baker, Daniel L., Parrill, Abby L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2705928/
https://ncbi.nlm.nih.gov/pubmed/19345587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.03.030
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