Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain

Endocannabinoids are lipid signaling molecules that regulate a wide range of mammalian behaviors, including pain, inflammation, and cognitive/emotional state. The endocannabinoid anandamide is principally degraded by the integral membrane enzyme fatty acid amide hydrolase (FAAH), and there is curren...

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Detalhes bibliográficos
Main Authors: Ahn, Kay, Johnson, Douglas S., Mileni, Mauro, Beidler, David, Long, Jonathan Z., McKinney, Michele K., Weerapana, Eranthie, Sadagopan, Nalini, Liimatta, Marya, Smith, Sarah E., Lazerwith, Scott, Stiff, Cory, Kamtekar, Satwik, Bhattacharya, Keshab, Zhang, Yanhua, Swaney, Stephen, Van Becelaere, Keri, Stevens, Raymond C., Cravatt, Benjamin F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692831/
https://ncbi.nlm.nih.gov/pubmed/19389627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.02.013
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