Tenofovir renal toxicity targets mitochondria of renal proximal tubules

Tenofovir disoproxil fumarate (TDF) is an analog of adenosine monophosphate that inhibits HIV reverse transcriptase in HIV/AIDS. Despite its therapeutic success, renal tubular side effects are reported. The mechanisms and targets of tenofovir toxicity were determined using ‘2 × 2’ factorial protocol...

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Detalhes bibliográficos
Main Authors: Kohler, James J, Hosseini, Seyed H, Hoying-Brandt, Amy, Green, Elgin, Johnson, David M, Russ, Rodney, Tran, Dung, Raper, C Michael, Santoianni, Robert, Lewis, William
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674517/
https://ncbi.nlm.nih.gov/pubmed/19274046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2009.14
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